Bombay Blood Type Test

The answer has to do with how we test for blood type. According to academic statistics roughly 1 in 17000 people in India test positive for the Bombay Blood Group a type that falls outside the regular A B O and AB groups and which was discovered by scientists in Bombay now Mumbai in 1952.

Full Text Bombay Blood Phenotype Laboratory Detection And Transfusions Recommendations International Journal Of Blood Transfusion And Immunohematology

Bombay and Para-Bombay Test Codes SREFFUT1 SREFFUT2 Recommended CPT Codes 81403 x each When Bombay or Para-Bombay type is suspected FUT1 or FUT1 testing may be warranted.

Bombay blood type test. The Bombay blood group also called hh is deficient in expressing antigen H meaning the RBC has no antigen H. It is only after a specific test for H Antigen in the blood is performed which can make a distinction between Bombay blood group and O blood group. Because the H Ag is common to all ABO blood group Bombay blood is incompatible with all ABO donors.

This testing is currently performed by a subcontracted laboratory using patient DNA prepared at the Red Cross. The Bombay would phenotype as an O blood group. Blood transfusions for the Bombay blood group with any other blood type.

The Bombay blood group looks O in a blood test no matter the real blood type. The degree of agglutination will tell you the ABO antigens present on that patients RBCs. A high level of consanguinity presents among the parents of the Bombay phenotype.

So there is tremendous chance of misinterpretation or unexploration of this Bombay blood group. They are only looking for A and B. Preferred Specimens 5 mL whole blood collectedin in an ACD-A or ACD-B yellow-top tube.

People usually have either of A B AB or O blood groups hich have H antigens. Forward typing uses commercial antisera anti-A and anti-B and patient red blood cells. ABO testing should include both forward and reverse typing.

So the blood test simply cant tell the difference between type O blood and the Bombay blood. Bombay blood group is a type of blood group that has no H antigen. FUT variant alleles are identified by Sanger sequencing.

Since Bombay blood group do not possess the A or B antigens it is usually comprehended as the O blood type. In routine forward grouping using anti-A anti-B and anti-AB. When Bombay blood group is misdiagnosed fatal hemolytic transfusion reactions occur.

The Bombay blood group is a very rare blood group discovered almost 60 years back. We report here a high risk case of Post Caesarean pregnancy with anaemia with Bombay Blood Group View. The rare Bombay blood group was first discovered in Mumbai then Bombay in 1952 by Dr Y M Bhende.

The result from forward typing is the patients blood type. The expression of A and B antigens is determined by the presence of H antigen on red blood cells. Different combinations of proteins on the outside of red blood cells determine blood type.

About 110 000 of the population in that region have Bombay blood group. Each red blood cell has antigen over its surface which helps determine which group it belongs to. It is an IgM antibody that can bind complement and cause red cell lysis.

If submitted with a CBC HbA1c or any other test requiring an EDTA lavender-top tube please submit a separate tube for this test. Reverse typing uses commercial red blood. This is due to the fact that a third antigen H on the surface of red cells can prevent the expected ABO blood type from occurring.

Reverse typing is a cross-check for. It is important to be cautious in predicting the ABO blood type of children based on the phenotypes of their parents. When misdiagnosed this Bombay group can cause fatal haemolytic transfusion reaction.

Serum from this individual contained antibodies that reacted with all RBCs from normal ABO phenotypes ie. Someone who doesnt have A or B is assumed to be normal type O. People having this blood type are mostly confined to Southeast Asia.

People in the Bombay blood group dont have the H antigen. The antigens of ABO group A B and H consist of complex carbohydrate molecules. Alternative Specimens Red-top tube no gel EDTA pink-top tube Cord blood EDTA lavender-top tube Note.

There are always exceptions to genetic rules. They also dont have the A antigen or B antigen. A suspension of 2-5 patient RBCs are made and antisera is added to individual tubes.

Caucasian incidence is 1250 000. People usually have either of A B AB or O blood groups hich have H antigens. Blood tests dont look for the H antigen.

In most diagnostic centres where blood tests are done only the presence and absence of AB and RH is tested in the blood. Bombay phenotype is one of the rarest ABO blood groups. The two most common tests used in the blood bank are the forward typing and reverse typing tests.

For this reason our suggestion is to incorporate routine serum typing. As because in our country there is routine practice of only forward or cell type grouping using finger prick method by voluntary blood donors organization and various blood banks. In Bombay India an individual was discovered to have an interesting blood type that reacted to other blood types in a way that had not been seen before.

Normally if an A blood type mother has an O type child the father is expected to be type O or at least to carry the O allele OO AO or BO genotype.

Full Text Bombay Blood Phenotype Laboratory Detection And Transfusions Recommendations International Journal Of Blood Transfusion And Immunohematology

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